American cancer researcher at Stanford University. In 2012 he was the first to discover that cancer cells use extra-chromosomal DNA (ecDNA)—tiny circular bodies of DNA that escape from chromosomes—to develop drug resistance at rates far faster than Mendel's laws of inheritance would normally allow. His work, published in Cell in 2026, showed that ecDNA is present in about 20% of human cancer samples and overwhelmingly carries defence mechanisms that help tumour cells replicate and evade destruction. Dr Mischel has identified the "anchor proteins" that allow ecDNA to reintegrate into chromosomes as promising therapeutic targets.
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